World

Iran hit its neighbors Pakistan and Iraq with missile strikes on Tuesday, prompting strong denunciations from both countries and raising fears that upheaval in the Middle East could spiral out of control.Since the war in Gaza began in October, Iran has used its proxy forces against Israel and its allies. But on Tuesday, it said its latest missile strikes had been in response to terrorist attacks within its borders.The missile strikes, nevertheless, raised tensions in a region where conflict has now touched at least five nations.“They are contributing to the escalation of regional tensions — and it must stop,” Catherine…

Roy Calne, a British surgeon whose work on organ transplantation helped turn what was once considered impossible into a lifesaving procedure for millions of people around the world, died on Jan. 6 at a retirement home in Cambridge, England. He was 93.His son Russell Calne said he died from heart failure.There are groundbreaking surgeons and groundbreaking researchers, but very few people are both. Dr. Calne (pronounced “kahn”) was an exception: He developed and practiced many of the operating techniques involved in transplantation, while at the same time working to identify what drugs would get the body to accept a new…

Christian Pulisic is perched on a bar stool in the old clubhouse overlooking the first-team training pitch at Milanello, AC Milan’s training ground.He makes a hand gesture, one he didn’t need the past six months living in Italy to learn. Pulisic is talking about himself as one of the “older guys” on the USMNT and, as he does so, he is sure to put air quotes around it.Nearby is a portrait of Milan legend Paolo Maldini lifting a trophy, a player who retired in his forties. Pulisic isn’t that age yet. He turned 25 shortly after joining Milan from Chelsea…

Despite staunch resistance from his opponents in the government, the anticorruption crusader Bernardo Arévalo was inaugurated early Monday morning as Guatemala’s president, a turning point in a country where tensions have been simmering over widespread graft and impunity.His inauguration had been scheduled for Sunday, but members of Congress delayed it, and concerns persisted about whether it would happen at all. But after an international outcry and pressure from protesters, Mr. Arévalo was sworn in shortly after midnight, becoming Guatemala’s most progressive head of state since democracy was re-established in the 1980s.His rise to power — six months after his victory…

There is a problem with the recently approved Alzheimer’s drug, Aduhelm. It can remove some of the amyloid that forms brain plaques that are hallmarks of the disease. But most of the drug is wasted because it hits an obstacle, the blood-brain barrier, that protects the brain from toxins and infections but also prevents many drugs from entering.Researchers wondered if they could improve that grim result by trying something different: they would open the blood-brain barrier for a short time while they delivered the drug. Their experimental method was to use highly focused pulses of ultrasound along with tiny gas…

It was late September when Naomi Osaka, the four-time Grand Slam champion and transcendent star of her sport, finally got on the phone with her former coach to talk about her next comeback. Wim Fissette is a cerebral Belgian who thinks long and hard before taking on a player, even one with a resume like Osaka’s. He had one, very serious question.Is it going to be different this time?There was then another conversation, with Florian Zitzelsberger, a 34-year-old German who is one of the most respected strength and conditioning coaches in the world. Zitzelsberger had worked with Osaka before, too. He…

Taiwan’s vice president, Lai Ching-te, who has faced sustained hostility from China, won the island democracy’s presidential election on Saturday, a result that could prompt Beijing to step up pressure on Taiwan, deepening tensions with Washington.For many of the millions of Taiwanese citizens who lined up at ballot booths on Saturday, the vote centered on the question of who should lead Taiwan in an increasingly tense standoff with its much larger, autocratic and heavily armed neighbor, China.They chose Mr. Lai, of the governing Democratic Progressive Party, or D.P.P., which wants to keep steering Taiwan away from Beijing’s influence, over Hou…